OBJECTIVE: To probe into the therapeutic effect of Bufei Huoxue capsule combined with budesonide/formoterol aerosol for inhalation on acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）complicated with pulmonary hypertension. METHODS: Totally 80 patients with AECOPD complicated with pulmonary hypertension admitted into this hospital from Jan. 2019 to Jan. 2021 were selected and divided into control group and study group via the random number table

with 40 cases in each group. The control group was given conventional symptomatic treatment

while the study group was given Bufei Huoxue capsule combined with budesonide/formoterol aerosol for inhalation based on the control group. The COPD Assessment Scale（ CAT） was used to assess life quality

the clinical efficacy

indicators of immunologic function[T-lymphocyte subpopulation CD3

+

CD4

+

and CD8

+

natural killer cell（ NK cell） ]

blood gas analysis [arterial partial pressure of oxygen（ PaO

2

）

arterial partial pressure of carbon dioxide（ PaCO

2

） and arterial oxygen saturation（ SaO

2

） ]

pulmonary function [forced expiratory volume in one second（ FEV

1

）

FEV

1

/forced vital capacity（ FVC） and peak expiratory flow（ PEF） ]

pulmonary artery pressure[pulmonary artery diastolic pressure（ PADP）

pulmonary artery systolic pressure（ PASP） and mean pulmonary artery pressure（ MPAP） ]

and 6 min walk test（ 6 MWT） distance were compared between two groups. RESULTS: The total effective rate was 87. 50%（ 35/40） in the study group

which was significantly higher than 65. 00%（ 26/40） in the control group

with statistically significant difference（ P

<

0. 05）. The CD3

+

CD4

+

NK cell

PaO

2

SaO

2

FEV

1

FEV

1

/FVC and PEF levels of both groups were increased after 14-day treatment

and those of the study group were significantly higher than the control group

with statistically significant differences（ P

<

0. 05）. The CD8

+

PaCO

2

PADP

PASP and MPAP levels of both groups decreased after treatment of 14 d

and those of the study group were significantly lower than the control group

with statistically significant differences（ P

<

0. 05）. The 6 MWT distance were prolonged and the CAT scores were decreased in both groups after discharge from hospital; the 6 MWT distance of study group was significantly longer than that of the control group

and the CAT score of study group was significantly lower than that of the control group

with statistically significant differences（ P

<

0. 05）. CONCLUSIONS: The combination of Bufei Huoxue capsule with budesonide/formoterol aerosol for inhalation in the treatment of AECOPD complicated with pulmonary hypertension can effectively improve patients ’ pulmonary function and blood gas level

reduce pulmonary arterial pressure

promote immunologic function

exercise tolerance and life quality

with remarkable therapeutic effect.