OBJECTIVE: To explore the effective material basis and mechanism of Qingshuang ointment in the treatment of psoriasis. METHODS: The active compounds and targets of three kinds of traditional Chinese medicine in Qingshuang ointment were searched by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform

GeneCards database was used to retrieve the related targets of psoriasis

and Venn diagram was constructed to obtain the therapeutic targets of Qingshuang ointment in the treatment of psoriasis. Cytoscape 3. 7. 0 was used to perform the “drugs-compounds-targets”network. Protein-protein interaction network（ PPI） was constructed based on the common targets of Qingshuang ointment and psoriasis. Gene ontology（ GO） functional enrichment analysis and Kyoto encyclopedia of genes and genomes（ KEGG） pathway enrichment analysis were performed via DAVID v6. 8 database. RESULTS: Taking drug-like properties ≥0. 18 as criteria

108 active compounds of Qingshuang ointment were screened

with 150 action targets. A total of 3 881 targets related to psoriasis were screened based on high correlation criteria

there were 82 common targets of drugs and diseases. PPI network was constructed

the most common targets were respectively IL-6

TP53

VEGFA

TNF

STAT3

PTGS2

CASP3

JUN and MAPK8. A total of501 results were included in the GO enrichment analysis. The KEGG signal pathway enrichment showed that the common target was expressed in 98 signal pathways. CONCLUSIONS: This study indicates that Qingshuang ointment exerts its therapeutic effects on psoriasis through multiple components and targets

and the mechanism mainly focuses on the regulation of HIF-1 signaling pathway

PI3 K-Akt signaling pathway

p53 signaling pathway

MAPK signaling pathway and vascular endothelial growth factor signaling pathway

which provides a scientific basis for the clinical application and experimental research of Qingshuang ointment.