OBJECTIVE: To evaluate the effects of medical order（ prescription） pre-review in reducing the ratio of irrational medical orders in pharmacy intravenous admixture service（ PIVAS）. METHODS: The PIVAS criteria for the First People’s Hospital of Chenzhou（ hereinafter referred to as “our hospital”） were set in accordance with the drug instructions

the Guidelines for Clinical Medication in Pharmacopoeia of the People ’s Republic of China（ 2015 edition） and other standards for drug combination

and the PIVAS prescription list was pre-reviewed by the Sky Health System. The PIVAS information system of our hospital were used to collect the results of medical order review from Jun. 20 to Jul. 20 in 2019

and from Jun. 20 to Jul. 20 in 2020. The results were classified according to seven aspects

including incompatibility

drug concentration

drug dose

administration method

solvent

medical advice input error and others. The proportion of inappropriate medical orders for the above two time periods was counted by Excel software according to department categories

and the results were analyzed by χ

2

test. RESULTS: Among the intravenous medical orders reviewed by PIVAS from Jun. 20 to Jul. 20 in 2019

the reasons for irrational administration were respectively compatibility（ 2. 05‰）

concentration（ 1. 71‰）

dose（ 1. 71‰）

mode or route（ 1. 65‰）

solvent（ 1. 11‰）

others（ 0. 97‰）

medication entry errors and duplication（ 0. 49‰） ． The proportion of irrational intravenous medical orders reviewed by PIVAS decreased significantly from 9. 78‰（ 1 308/133 715） from Jun. 20 to Jul. 20 in 2019 to 3. 59‰（ 472/131 478） from Jun. 20 to Jul. 20 in 2020

with statistically significant difference（ P

<

0. 001）. CONCLUSIONS: Strengthening the pre-review by pharmacists is the important guarantee for reducing the rate of irrational prescriptions in PIVAS and improving the rationality of medication.