OBJECTIVE: To evaluate the management quality of clinical application of antibiotics in hospitals

and to provide reference for decision-making of antimicrobial stewardship in hospitals. METHODS: Indicators related to the quality evaluation of antimicrobial stewardship in Fudan University Shanghai Cancer Center（ hereinafter referred to as“our hospital”） from 2012 to 2020 were extracted from the hospital information system. Ten indicators were selected for analysis matrix

including the antimicrobial use rate

antibiotics use density

perioperative prophylactic medication for type Ⅰ incision surgery and microbiological detection rate of therapeutic drugs. Entropy weight-technique for order preference by similarity to ideal solution（ TOPSIS） method was used to calculate the relative proximity（ Ci） of each year for the comprehensive evaluation of management quality. RESULTS: Based on entropy weight-TOPSIS method

the Ci from 2012 to 2020 ranged from 0. 218 8 to 0. 760 2. The Ci in 2012 was 0. 218 8

indicating the worst quality of antimicrobial stewardship in our hospital. The Ci in 2020 was 0. 760 2

indicating the best quality of antimicrobial stewardship in our hospital. 2013

2017 and 2018 were three years of rapid improvement in the quality of antimicrobial stewardship in our hospital. From 2017 to 2020

the quality of antimicrobial stewardship in our hospital was improved.CONCLUSIONS: The quality of antimicrobial stewardship in our hospital shows an overall trend of improvement. The entropy-weighted TOPSIS method can objectively and comprehensively evaluate the quality of antimicrobial stewardship

and provide reference for hospital decision-making and program development of antimicrobial stewardship.