OBJECTIVE: To investigate the application of antibiotics in various medical institutions at all levels in district A of Shanghai（ hereinafter referred to as “this district”）

so as to provide information for the improvement of relevant management policies in this district. METHODS: The application rate of antibiotics（ %）

application intensity of antibiotics[DDDs/（ 100 persons·d） ]and prophylactic application rate of antibiotics in type I incision surgery（ %）of outpatients and inpatients in 20 medical institutions from 2014 to 2019 were collected and analyzed statistically.Meanwhile

variables such as the number of medical staff

annual outpatient visits

annual hospital admissions and year were introduced for panel regression analysis. RESULTS: From 2014 to 2019

the application rate and application intensity of antibiotics in inpatients of secondary medical institutions showed the decreasing trend

while the prophylactic application rate of antibiotics in type I incision surgery was in the increasing trend. The application rate of antibiotics in outpatients

inpatients and application intensity in inpatients in primary medical institutions showed the decreasing trend. In addition

the year significantly affected the application of antibiotics in inpatients of primary and secondary medical institutions

yet in different directions. CONCLUSIONS: The overall application rate of antibiotics in outpatients is basically rational. Yet the application rate of antibiotics in inpatients of primary medical institutions is relatively high. In recent years

the prophylactic application rate of antibiotics for type I incision surgery in secondary medical institutions has exceeded the requirements of national guidelines

and the application rate of antibiotics for inpatients in secondary medical institutions has decreased significantly.