基于有效成分含量测定探讨中药青黛的合理服用方法

郭丹丹; 徐静; 郝永彪; 李隽; 陈爱芳

doi:10.14009/j.issn.1672-2124.2021.12.016

您当前的位置：

首页 >

文章列表页 >

基于有效成分含量测定探讨中药青黛的合理服用方法

论著 | 更新时间：2022-10-08

- 基于有效成分含量测定探讨中药青黛的合理服用方法
- Exploration on Rational Administration of Traditional Chinese Medicine Indigo Naturalis Based on Effective Content Determination
- 中国医院用药评价与分析 2021年21卷第12期页码：1490-1493
- 作者机构：
  
  北京王府中西医结合医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.12.016
  中图分类号： R286.0
- 纸质出版日期：2021，
扫描看全文
郭丹丹, 徐静, 郝永彪, 等. 基于有效成分含量测定探讨中药青黛的合理服用方法[J]. 中国医院用药评价与分析, 2021,21(12):1490-1493.

GUO Dandan, XU Jing, HAO Yongbiao, et al. Exploration on Rational Administration of Traditional Chinese Medicine Indigo Naturalis Based on Effective Content Determination[J]. 2021,21(12):1490-1493.
郭丹丹, 徐静, 郝永彪, 等. 基于有效成分含量测定探讨中药青黛的合理服用方法[J]. 中国医院用药评价与分析, 2021,21(12):1490-1493. DOI： 10.14009/j.issn.1672-2124.2021.12.016.

GUO Dandan, XU Jing, HAO Yongbiao, et al. Exploration on Rational Administration of Traditional Chinese Medicine Indigo Naturalis Based on Effective Content Determination[J]. 2021,21(12):1490-1493. DOI： 10.14009/j.issn.1672-2124.2021.12.016.

摘要

目的:基于中药青黛、青黛包煎液和不同厂家青黛配方颗粒中有效成分（靛蓝和靛玉红）的含量测定

以及其含量差异的分析

探讨青黛的临床合理服用方法。方法:采用液相检测

色谱柱为Waters XBridge C

柱（4.6 mm×250 mm

5μm）;进样量为10μl;以甲醇-水（V∶V=70∶30）为流动相进行洗脱

流速为1.0 ml/min;柱温为35℃; PDA检测器检测波长为606 nm（靛蓝）、292 nm（靛玉红）

同时测定青黛饮片、包煎液和颗粒中靛蓝和靛玉红的含量。结果:青黛饮片中靛蓝、靛玉红的含量为15.5%、0.18%

青黛颗粒1中靛蓝、靛玉红的含量为4.9%、0.14%

青黛颗粒2中靛蓝、靛玉红的含量为8.8%、0.13%

均符合《中华人民共和国药典:一部》（2020年版）的要求（靛蓝含量不得少于2%

靛玉红含量不得少于0.13%）。在青黛饮片、青黛包煎液和青黛配方颗粒中

青黛饮片中靛蓝、靛玉红含量最高。结论:根据实验结果

推荐临床上使用青黛饮片时直接冲服或入丸剂、散剂

效果较好

不建议采用青黛布包后入煎剂的方式。

Abstract

OBJECTIVE: To determine the content（ indigo and indirubin） in indigo naturalis

indigo naturalis decoction and indigo naturalis formula granules from different manufacturers

and to analyze the content difference

so as to explore the rational clinical administration of indigo naturalis. METHODS: The separation was performed on the Waters XBridge C

column（ 4. 6 mm × 250 mm

5 μm） by using liquid phase detection

with sample size of 10 μl.The mobile phase was methanol-water（ V∶ V = 70 ∶ 30）

and the flow rate was 1. 0 ml/min. The column temperature was 35 ℃ ． The detection wavelength of PDA detector was 606 nm（ indigo） and 292 nm（ indirubin）

the contents of indigo and indirubin in indigo naturalis decoction pieces

decoction and granules were determined. RESULTS: The contents of indigo and indirubin in indigo naturalis decoction pieces were 15. 5% and 0. 18%

the contents of indigo and indirubin in indigo naturalis granules 1 were 4. 9% and 0. 14%

and the contents of indigo and indirubin in indigo naturalis granules 2 were 8. 8% and 0. 13%

all of which met the requirements of the Pharmacopoeia of the People’s Republic of China（ Part Ⅰ

2020 edition）（ the range of indigo was no less than 2%

the range of indirubin was no less than 0. 13%）. Among the indigo naturalis decoction pieces

decoction and granules

the content of indigo and indirubin was the highest in indigo naturalis decoction pieces. CONCLUSIONS: According to the experimental results

it is clinically recommended to use indigo naturalis decoction pieces for direct brewing or into pills and dispersal

which is more effective

rather than indigo naturalis packet decoction.

关键词

青黛颗粒靛蓝靛玉红

Keywords

Indigo naturalisGranulesIndigoIndirubin

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

暂无数据