OBJECTIVE: To explore the effects of labetalol tablets combined with modified Pinggan Jiangya decoction on high mobility group protein B1（ HMGB1）

heme oxygenase 1（ HO-1） and macrophage scavenger receptors in patients with essential hypertension 1（ MSR1） influence. METHODS: A total of 146 patients with essential hypertension admitted to Kailuan General Hospital from Sept. 2016 to Sept. 2020 were selected as the research subjects. They were divided into the labeolol group and the combined treatment group according to the random number table method

with 73 patients in each group. Patients in the labeolol group were treated with labeolol tablets

and patients in the combined treatment group were treated with modified Pinggan Jiangya decoction on the basis of labeolol tablets. Blood pressure

TCM syndrome score and treatment effect of 2 groups were observed

and the contents of renal function indicators such as serum creatinine

serum uric acid

blood urea nitrogen and urinary microalbumin were detected. The levels of interleukin 6

tumor necrosis factor α

hypersensitive C-reactive protein and serum HMGB1

HO-1 and MSR1 were detected. RESULTS: Compared with labeolol group

blood pressure indexes

liver function indexes

renal function indexes

inflammatory factor levels

serum HMGB1

HO-1 and MSR1 levels

and TCM syndrome scores in the combined treatment group were significantly lower

with statistical significance（ P <0. 05）. The total effective rate of combined treatment group was 95. 89%（ 70/73）

which was significantly higher than that of labeolol group（ 84. 93%

62/73）

and the difference was statistically significant（ P < 0. 05）.CONCLUSIONS: The modified Pinggan Jiangya decoction combined with labetalol tablets can effectively improve the clinical symptoms and blood pressure level

reduce HMGB1

HO-1 and MSR1 levels in patients with essential hypertension.