OBJECTIVE: To probe into the efficacy of Milnacipran hydrochloride tablets combined with Shugan Jieyu capsules in the treatment of anxiety and depression after cervical cancer chemotherapy and its effects on lymphocyte subsets

sleep and quality of life. METHODS: Totally 80 patients with anxiety and depression after cervical cancer chemotherapy admitted into People’s Hospital of Xinjiang Uygur Autonomous Region from Jan. 2019 to Oct. 2020 were extracted to be divided into the control group and the observation group via the random number table

with 40 cases in each group. On the basis of the conventional psychological interventions

the control group was treated with Shugan Jieyu capsules

while the observation group received Milnacipran hydrochloride tablets combined with Shugan Jieyu capsules. Self-rating anxiety scale（ SAS）

self-rating depression scale（ SDS）

Pittsburgh sleep quality index（ PSQI） and quality of life（ QOL） were used to evaluate the anxiety

depression

sleep and life quality in two groups. The serum levels of 5-hydroxytryptamine（ 5-HT） and norepinephrine（ NE）

T lymphocyte subsets and the incidence of adverse drug reactions were observed in both groups. RESULTS: After treatment

the SAS score and SDS score of the observation group were significantly lower than those of the control group

and the serum levels of 5-HT and NE were significantly higher than those of the control group

with statistically significant differences（ P

<

0. 05）.The detection results of T lymphocyte subsets showed that the levels of CD4

+

and CD4

+

/CD8

+

in the observation group were significantly higher than those in the control group after treatment

and the levels of CD8

+

were significantly lower than those in the control group

the differences were statistically significant（ P

<

0. 05）. The PSQI score of the observation group after treatment was significantly lower than that of the control group

and the QOL score was significantly higher than that of the control group

with statistically significant differences（ P

<

0. 05）. The incidences of adverse drug reactions in the observation group and control group were respectively 30. 0%（ 12/40） and 20. 0%（ 8/40）

and the difference was not statistically significant（ χ

2

= 1. 07

P = 0. 30）. CONCLUSIONS:Milnacipran hydrochloride tablets combined with Shugan Jieyu capsules in the treatment of anxiety and depression after cervical cancer chemotherapy is significant with higher safety

which can relieve the anxiety and depression in patients

improve the cellular immune function

and promote the quality of sleep and life.