OBJECTIVE: To explore the efficacy of Longzhu ointment combined with three-level pressure ulcer therapy in the prevention and treatment of pressure ulcers in patients with a high risk of stroke and pressure ulcers > 60 years old. METHODS: Totally 82 patients with stroke complicated with out-of-hospital pressure ulcer admitted into Beijing Luhe Hospital Affiliated to Capital Medical University from Jun. 2017 to Jun. 2020 were selected and divided into control group and observation group by random number table method

with 41 cases in each group. With no intervention on the treatment of patients

the control group was treated and intervened by the charge nurse according to pressure ulcer staging and assessment; while the observation group received Longzhu ointment on the traumatic surface with the procedure of tertiary therapy of pressure ulcer. The clinical efficacy of pressure ulcer

the distribution of pressure ulcers in different grades after treatment

the diameter of pressure ulcer surface before and after treatment

the recurrence rate of pressure ulcer within 6 months of discharge and the satisfaction rate were compared between two groups. RESULTS: The total effective rate of pressure ulcer treatment in the observation group was 97. 56%（ 40/41）

which was higher than 85. 37%（ 35/41） in the control group

and the difference was statistically significant（ P <0. 05）. After treatment

the distribution of pressure ulcers in the observers was better than that in the control group

and the difference was statistically significant（ P < 0. 05）. After 7

14

21 and 30 days of treatment

the diameter of the pressure sore of the observer patients was significantly smaller than that of the control group

and the difference was statistically significant（ P < 0. 05）. Within 6 months of discharge

the recurrence rate of pressure ulcers in the observer patients was 9. 76%（ 4/41）

which was lower than 26. 83%（ 11/41） in the control group

and the difference was statistically significant（ P < 0. 05）. The total satisfaction of the observer patients was 100%（ 41/41）

which was higher than 78. 05%（ 32/41） of the control group

and the difference was statistically significant（ P < 0. 05）.CONCLUSIONS: The application of Longzhu ointment combined with tertiary therapy of pressure ulcer is beneficial to the prevention and treatment of pressure ulcer in elderly patients with stroke who are in long-term bedridden

with obvious intervention effect and high clinical application value.