OBJECTIVE: To probe into the clinical efficacy of Getong Tongluo capsules combined with flunarizine in the treatment of vertigo of vertebro-basilar insufficiency. METHODS: Totally 102 patients with vergito of vertebrobasilar insufficiency admitted into Liaocheng Second People’s Hospital from Jun. 2019 to Dec. 2020 were extracted to be divided into control group and observation group via random number table

with 51 cases in each group. The control group was given flunarizine

while the observation group was given Getong Tongluo capsules combined with flunarizine

both groups were treated for 2 weeks. Evaluation of clinical efficacy was conduct after treatment; the blood flow velocity of basilar artery

left vertebral artery and right vertebral artery

levels of serum calcitonin gene-related peptide（ CGRP） and endothelin-1（ ET-1） before and after treatment were compared between two groups. RESULTS: The clinical total effective rate of observation group was 90. 20%（ 46/51）

which was significantly higher than that of the control group（ 70. 59%

36/51）

with statistically significant difference（ P < 0. 05）. The onset time of dizziness of observation group was significantly shorter than that of the control group

and the frequency of dizziness onset was significantly lower than that of the control group

with statistically significant differences（ P < 0. 05）. After treatment

the blood flow velocity of basilar artery

left vertebral artery and right vertebral artery

and the serum CGRP levels of both groups were significantly higher than those of before treatment

and the above-mentioned indicators of observation group were significantly higher than those of the control group

with statistically significant differences（ P < 0. 05）.After treatment

the serum ET-1 levels of both groups were significantly lower than those of before treatment

and the serum ET-1 level of observation group were significantly lower than that of the control group

with statistically significant differences（ P < 0. 05）. CONCLUSIONS: The efficacy of Getong Tongluo capsules combined with flunarizine in the treatment of vertigo of vertebro-basilar insufficiency is remarkable

which can significantly reduce the symptoms of vertigo

improve the vertebro-basilar hemodynamics and serum CGRP and ET-1 levels.