OBJECTIVE: To probe into the effects of Yinxingye capsules combined with alprostadil injection on cerebral blood flow

serum homocysteine（ Hcy） and fibroblast growth factor 21（ FGF21） in patients with posterior circulation ischemic vertigo（ PCIV）. METHODS: Totally 224 patients with PCIV admitted into People’s Hospital of Xinjiang Uygur Autonomous Region from Jan. 2019 to Oct. 2020 were retrospectively extracted. The control group（ 104 patients） was treated with alprostadil injection

while the observation group（ 120 patients） received Yinxingye capsules combined with alprostadil injection. The course of treatment was 2 weeks. Clinical efficacy

clinical symptom score

blood flow velocity of vertebrobasilar artery and levels of serum Hcy and FGF21 were observed in two groups.RESULTS: After treatment of two weeks

the total effective rate of the observation group was 92. 5%（ 111/120）

significantly higher than that of the control group 83. 7%（ 87/104）

the difference was statistically significant（ P <0. 05）. After treatment

the scores of vertigo degree

vertigo duration

vertigo frequency and accompanying symptoms in patients with PCIV in the observation group were significantly lower than those in the control group

the differences were statistically significant（ P < 0. 05）. After treatment

the blood flow velocity of left vertebral artery

right vertebral artery and basilar artery of the observation group was significantly faster than that of the control group

and the levels of serum Hcy and FGF21 were significantly lower than those of the control group

the differences were statistically significant（ P < 0. 05）. CONCLUSIONS: The efficacy of Yinxingye capsules combined with alprostadil injection in the treatment of patients with PCIV is significant

which can effectively improve the clinical symptoms and cerebral blood flow

reduce the levels of serum Hcy

FGF21.