OBJECTIVE: To explore the mechanism of Jingfang granules in the treatment of influenza based on network pharmacology and molecular docking technology. METHODS: The components and targets of Jingfang granules were investigated by traditional Chinese medicine systems pharmacology database and analysis platform（ TCMSP）.GeneCards database was used to retrieve the targets of influenza

and the potential targets of Jingfang granules in the treatment of influenza were obtained. Protein-protein interaction（ PPI） network analysis was performed on the potential targets through the STRING database. Gene ontology（ GO） and Kyoto encyclopedia of genes and genomes（ KEGG）enrichment analysis of potential targets were performed by R software RStudio． “Drug-component-potential targets”network was constructed by using Cytoscape 3. 7. 2. Autodock was used to carry out the molecular docking of important active components and key targets. RESULTS: A total of 159 components that met the screening criteria（ OB≥30%

DL≥0. 18） of Jingfang granules were retrieved

and 2 574 targets for influenza were collected

and 54 targets were obtained as potential targets for the treatment of influenza with Jingfang granules by taking the intersection. GO and KEGG enrichment analysis showed that Jingfang Granule played an essential role in the treatment of influenza mainly through acting on influenza A signaling pathway

MAPK signaling pathway

TNF signaling pathway. Quercetin

luteolin

beta-sitosterol

kaempferol

naringin and wogonin were important effective components of Jingfang granules in the treatment of influenza. PTGS2

PRSS1

ADRB2

MAPK14 and RELA were key targets in the treatment of influenza. Through molecular docking

it was found that quercetin

luteolin

beta-sitosterol

kaempferol and wogonin had low binding energy and good affinity with related targets. CONCLUSIONS: Jingfang granules may inhibit influenza virus and regulate immune response of the body by acting on targets such as PTGS2

PRSS1

ADRB2

MAPK14 and RELA and regulating influenza A signaling pathway

TNF signaling pathway

MAPK signaling pathway and IL-17 signaling pathway.