OBJECTIVE: To investigate the compatibility of medicines in medical orders from the National Clinical Research Base of Traditional Chinese Medicine Hebei Provincial Hospital of Traditional Chinese Medicine（ hereinafter referred to as“our hospital”） before and after the implementation of multiple measures

so as to improve the safety and effectiveness of traditional Chinese medicine injection. METHODS: In Jul. 2020

our hospital began to implement multiple measures on irrational medical orders of traditional Chinese medicine injection. Retrospective method was adopted to investigate inpatient medical orders of traditional Chinese medicine injection before intervention（ from Jan. to Jun. 2020） and after intervention（ from Jul. to Dec. 2020）. The irrational compatibility of medical orders was statistically analyzed to compare the irrational compatibility rate of medical orders of traditional Chinese medicine injection and the effectiveness of intervention measures before and after intervention. RESULTS: Before intervention

among 18 917 medical orders of traditional Chinese medicine injection

299 were found to have irrational compatibility

and the irrational compatibility rate of traditional Chinese medicine injection was 1. 58%. After intervention

among 23 593 medical orders of traditional Chinese medicine injection

306 were found to have irrational compatibility

and the irrational compatibility rate of traditional Chinese medicine injection was 1. 30%（ 17. 72% lower than before intervention）. After intervention

among the irrational compatibility of traditional Chinese medicine injection

the proportion of medical orders decreased the most in the case of incorrect input of medical orders and mixed infusion of Chinese and Western medicines

followed by improper selection of drug dosage and solvent dosage

indicating that multiple measures can effectively improve the irrational compatibility of traditional Chinese medicine injection. CONCLUSIONS: The use of information technology and administrative intervention and other measures of PDCA cycle management to intervene in the compatibility of medicines in medical orders for traditional Chinese medicine injection can effectively improve the level of rational compatibility of traditional Chinese medicine injection and guarantee the medication safety for patients.