OBJECTIVE: To evaluate and explore the intervention measures for pharmaceutical administration and rational drug use of key monitored drugs. METHODS: In 2019

the Inner Mongolia People’s Hospital（ hereinafter referred to as “our hospital ”） implemented clinical application management measures for key monitored drugs.Retrospective analysis was used to extract relevant data of drugs in the key monitored catalogue of our hospital before intervention（ from Jul. to Dec. 2018） and after intervention（ from Jul. to Dec. 2019 and from Jul. to Dec. 2020）. The drug utilization evaluation and rationality of drug use were set as the evaluation indicators

the overall use and rationality of drugs were monitored before and after intervention. RESULTS: Compared with before intervention

the consumption sum of key monitored drugs in our hospital and the proportion in total consumption sum

medication frequency and drug proportion showed the decreasing trend after intervention. Drugs with large changes in defined daily cost were respectively troxerutin cerebroprotein hydrolysate injection and osteopeptide injection. Among 20 key monitored drugs

the ratio of drug consumption sum ranking/medication frequency ranking of 16 drugs was from 0. 5 to 1. 5. The incidence of irrationality decreased month by month after intervention（ from Jul. to Dec. 2019）.CONCLUSIONS: Through pharmaceutical administration and intervention measures of rational drug use

the consumption sum of drugs decrease significantly

and the irrational drug use has been significantly improved

which promote the reasonable use of key monitored drugs.