OBJECTIVE: To compare the efficacy and safety of Amlodipine besylate folic acid tablets and Enalapril maleate folic acid tablets in the treatment of H-type hypertension patients. METHODS: A total of 160 Guangxi Zhuang patients diagnosed with H-type hypertension for the first time in Wuming Hospital

Guangxi Medical University from Jan. 2019 to Jan. 2020 were extracted to be divided into the observation group and the control group via the random number table

with 80 cases in each group. The observation group was treated with Amlodipine besylate folic acid tablets

while the control group received Enalapril maleate folic acid tablets

both groups were treated for 6 months.Clinical efficacy

blood pressure [systolic pressure（ SBP） and diastolic pressure（ DBP） ]

homocysteine（ Hcy）level

adverse drug reactions and cardiovascular and cerebrovascular adverse events before and after treatment in two groups were observed. RESULTS: The total effective rate of the observation group and the control group was respectively 88. 75%（ 71/80） and 83. 75%（ 67/80）

the total effective rate of the observation group was higher than that in the control group

the difference was not statistically significant（ P>0. 05）. Compared with before treatment

the levels of SBP

DBP and Hcy in two groups decreased significantly after treatment

and the decrease of SBP

DBP and Hcy in the observation group was greater than that in the control group

the differences were statistically significant（ P<0. 05）. Within 6 months of treatment

the incidence of cardiovascular and cerebrovascular adverse events was 3. 75%（ 3/80） in the observation group and 10. 00%（ 8/80） in the control group

with no statistically significant difference（ P > 0. 05）. The incidence of adverse drug reactions was 6. 25%（ 5/80） in the observation group

significantly lower than 16. 25%（ 13/80） in the control group

the difference was statistically significant（ P<0. 05）.CONCLUSIONS: Amlodipine benzoate folic acid tablets for H-type hypertension patients shows better results in lowering blood pressure and Hcy levels and lower incidence of adverse drug reactions.