OBJECTIVE: To evaluate the effects of improving and upgrading the management system of pharmacy intravenous admixture service（ PIVAS） in the First Affiliated Hospital of Xi’an Jiaotong University（ hereinafter referred to as “our hospital”） on work quality and efficiency. METHODS: At the end of 2019

our hospital redesigned and optimized the function and architecture of PIVAS

including upgrading the post-review of medical orders to pre-review

optimizing drug batch and bottle label printing. Medical orders implemented in PIVAS of our hospital from 2019 to2020 were retrospectively analyzed. According to different implementation time of new PIVAS system

the medical orders in 2019 were extracted as before improvement

and the medical orders in 2020 were extracted as after improvement

and the interception rate and work efficiency of irrational medical orders before and after improvement were compared. RESULTS: After improvement

the rate of interception of irrational medical orders in PIVAS of our hospital was significantly higher than those before improvement

and the difference was statistically significant[4. 38‰（ 8 533/1 948 511） compared with 0. 90‰（ 1 724/1 915 675）

χ

2

= 4 417. 150

P

<

0. 001]. After improvement

the interception rate of irrational medical orders for conventional drugs[0. 64‰（ 1 253/1 948 511） compared with 0. 19‰（ 355/1 915 675）

χ

2

= 486. 587

P

<

0. 001]

the interception rate of irrational medical orders for cytotoxic drugs[0. 15‰（ 293/1 948 511） compared with 0. 01‰（ 26/1 915 675）

χ

2

= 218. 996

P

<

0. 001]and the interception rate of irrational medical orders for total parenteral nutrition drugs[0. 09‰（ 176/1 948 511） compared with 0. 02‰（ 44/1 915 675）

χ

2

= 76. 982

P

<

0. 001] were significantly higher than those before improvement

the synchronization time of medical orders（ t = 101. 468

P

<

0. 001）

batch optimization time（ t = 129. 802

P

<

0. 001） and printing time（ t= 57. 816

P

<

0. 001） were significantly shorter than those before improvement

with statistically significant differences. CONCLUSIONS: The upgraded PIVAS management system has significantly improved the work quality and efficiency in all aspects of PIVAS

which is worth promoting and applying.