OBJECTIVE: To evaluate the potentially inappropriate medication（ PIM） in elderly patients with multiple drug use based on two criteria in the geriatrics department of Zhongshan Hospital Affiliated to Xiamen University（ hereinafter referred to as “our hospital”）

and to explore the influencing factors of PIM. METHODS: The electronic medical record system was used to retrospectively collect the relevant information of inpatients and outpatients in our hospital. Based on the Beers criteria（ Version 2019） and the Chinese Catalogue of Potentially Inappropriate Medication for the Elderly（ hereinafter referred to as the “Chinese PIM criteria”）

the PIM types were evaluated

and the binary logistic regression method was used to analyze the influencing factors of PIM.RESULTS: A total of 140 elderly patients with multiple drugs（ 69 inpatients and 71 outpatients） were enrolled. Totally 41 patients（ 29. 29%） were detected with PIM by using the Beers criteria（ Version 2019）

and 88 patients（ 62. 86%） were detected with PIM by using the Chinese PIM criteria. Logistic regression analysis showed that among the influencing factors for PIM screened by the Beers criteria（ Version 2019）

drug quantity and age-adjusted Charlson comorbidity index（ aCCI） were the risk factors（ OR>1

P<0. 05）

and endogenous creatinine clearance was the protective factor（ OR<1

P < 0. 05）. According to Chinese PIM criteria

only drug quantity was screened as the risk factor for PIM（ OR>1

P<0. 05）.CONCLUSIONS: There are certain differences between the Beers criteria（ Version 2019） and the Chinese PIM criteria

it is recommended that the combination should be used.Clinically

the number of drugs used and the risk of aCCI for PIM should be paid attention to. For elderly patients with multiple drugs

individualized drug management should be attached more importance.