OBJECTIVE: To investigate the clinical application of polymyxin B sulfate for injection in Hainan General Hospital（ hereinafter referred to as “our hospital”）

so as to provide reference for the rational use of polymyxin B sulfate for injection. METHODS: Patients admitted into our hospital from Jan. 1 st

2018 to Mar. 15 th

2021 and received polymyxin B sulfate for injection were selected as the research objectives. The basic information

results of pathogen examination

usage and dosage of polymyxtin B sulfate for injection

drug combination

treatment outcome and adverse drug reactions were analyzed retrospectively. RESULTS: A total of 51 patients were enrolled in the study

including 34 males（ 66. 67%） and 17 females（ 33. 33%）

with an average age of（ 61. 31 ± 17. 98） years. Totally137 pathogenic positive specimens were detected

and 115 strains of Gram-negative bacteria were detected

the detection rate of Gram-negative bacteria was 83. 94%

among which 55 strains（ 47. 83%） of extensively drug-resistant and multidrug resistant Gram-negative bacteria. The usage and dosage of polymyxin B sulfate for injection were in line with the requirements of the drug instructions. The average duration of medication was（ 11. 75 ± 8. 81） d. Most of the drug combination were carbapenems. Due to the reatment course of polymycin B sulfate for injection in two patients was less than 2 d

the efficacy was evaluated in 49 patients

and the anti-infective efficiency was 30. 61%（ 15/49）. Among 51 patients with polymyxin B sulfate for injection

22 cases had acute kidney injury（ 43. 14%）

and 2 cases had skin pigmentation（ 3. 92%）. CONCLUSIONS: The clinical application of polymyxin B sulfate for injection still needs to be strictly managed

and adverse drug reactions such as nephrotoxicity and skin pigmentation should be concerned.