OBJECTIVE: To systematically evaluate the efficacy and safety of Fuyang granules combined with antihistamines in the treatment of chronic urticaria（ CU）. METHODS: PubMed

the Cochrane Library

EMBase

Wanfang data base

CNKI and CBM database were retrieved to collect the randomized controlled trial（ RCT） of Fuyang granules combined with antihistamines in the treatment of CU（ the study group was given Fuyang granules combined with antihistamines

while the control group received antihistamines）. The retrieval time was from the establishment of the database to May 2021. Meta-analysis was performed by using RevMan 5. 4 software after selection of literature

extraction of information and evaluation of risk of bias in the included literature by two researchers. RESULTS: Totally10 RCT were collected

including 873 patients（ 451 patients in the study group and 422 patients in the control group）.Meta-analysis showed that the total effective rate（ OR = 4. 31

95%CI = 2. 78-6. 68

P<0. 000 01）

significant effective rate（ OR = 1. 42

95% CI = 1. 06-1. 91

P = 0. 02）

cure rate（ OR = 2. 56

95% CI = 1. 83-3. 59

P < 0. 000 01） and recurrence rate（ OR = 0. 29

95%CI = 0. 12-0. 68

P = 0. 004） in the study group were significantly better than those in the control group

and the differences were statistically significant. The incidence of adverse drug reactions in the study group was significantly lower than that in the control group

with statistically significant difference（ OR = 0. 43

95%CI =0. 26-0. 71

P = 0. 001）. CONCLUSIONS: Existing evidence shows that Fuyang granules combined with antihistamines is safe and effective in the treatment of CU with lower recurrence rate

and has obvious advantages over the use of antihistamines alone. Limited by the quantity and quality of selected RCT

the above conclusions need to be verified by more high-quality RCT in the future.