OBJECTIVE: To establish the chromatographic fingerprint by high performance liquid chromatography（ HPLC） for Shengjiang Xiexin decoction

so as to provide reference for quality control and clinical application of Shengjiang Xiexin decoction. METHODS: Different batches of herbal decoction pieces as ingredients of Shengjiang Xiexin decoction were collected. Ten batches of Shengjiang Xiexin decoction were prepared according to the origin area and batch number. The decoction of Shengjiang Xiexin decoction was analyzed by HPLC

and the fingerprint analysis method was investigated. The fingerprints were analyzed by he Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine（ 2004 A）

and the common peaks were identified by the main chemical components of the control. RESULTS: The accuracy

reproducibility and stability test showed that the RSD of common peaks’ retention time（ RT） and peak area（ PA） were <2% and <5%

respectively. Totally 41 well separated common peaks were found in the fingerprints

in which 9 common peaks were identified as 6-gingerol and chlorogenic acid. The similarity of 10 batches of Shengjiang Xiexin decoction was > 0. 99. CONCLUSIONS: The fingerprint method established in the study has good precision

reproducibility and stability

which can provide basis for the quality control and pharmacological study of Shengjiang Xiexin decoction.