OBJECTIVE: To probe into the efficacy of Anshen Ningxin capsule on the perimenopausal metabolic syndrome

and its effect on estrogen secretion level and metabolism-related indicators. METHODS: Totally 140 patients with perimenopausal metabolic syndrome（ liver-depression and spleen-deficiency type） admitted into Xintai Hospital of Traditional Chinese Medicine from 2018 to 2019 were selected and divided into control group and observation group via the random number table

with 70 cases in each group. The control group was given estradiol valerate and dydrogesterone orally

while the observation group was treated with Anshen Ningxin capsule on the basis of control group. The traditional Chinese medicine（ TCM） syndrome integral

TCM syndrome efficacy

estrogen secretion level[estradiol（ E2）

leuteinizing hormone（ LH） and follicle-stimulating hormone（ FSH） ]

fasting blood glucose

fasting blood lipid [triglyceride（ TG） and high density lipoprotein-cholesterol（ HDL-C） ]

waist circumference（ WC）

body mass index（ BMI）

blood pressure [systolic pressure（ SP）

diastolic pressure（ DP） ] before and after treatment were compared between two groups. RESULTS: After treatment

the TCM syndrome integral of two groups were significantly decreased

the secretion levels of E2

FSH and LH were significantly improved

the fasting blood glucose

TG

BMI

WC

SP and DP levels were significantly decreased

while the HDL-C was significantly increased

with statistically significant differences（ P<0. 05）; all the above indicators in observation group were significantly better than those of the control group

with statistically significant differences（ P<0. 05）. After treatment

the total effective rate of TCM syndromes in the observation group was 90. 0%（ 63/70）

which was significantly higher than that of the control group（ 74. 3%

52/70）

with statistically significant difference（ P < 0. 05）. CONCLUSIONS: The efficacy of Anshen Ningxin capsule in the treatment of perimenopausal metabolic syndrome（ liver-depression and spleen-deficiency type）is remarkable

which can regulate estrogen secretion level

and interfere with metabolism-related indicators.