OBJECTIVE: To probe into the molecular mechanism of Biyuan Tongqiao granule in the treatment of rhinitis based on network pharmacology and molecular docking. METHODS: To collect the active components and effect targets through Traditional Chinese Medicine Systems Pharmacology Database And Analysis Platform（ TCMSP）

Traditional Chinese Medicines Integrated Database（ TCMID） and related literature. The disease genes related to rhinitis were retrieved by OMIM

GeneCards

Dis GeNET

GenCLiP and TTD disease database. The “drug-compoundtarget”network

rhinitis related PPI network

“compound-target ” network of Biyuan Tongqiao granules in the treatment of rhinitis

PPI network of Biyuan Tongqiao granule in the treatment of rhinitis and “key compound-core target-pathway” network were constructed by Cytoscape

the Go function and KEGG pathway enrichment were conducted by adopting R software. The Autodock＿vina software was used to conduct molecular docking on the screened key compounds and core targets. RESULTS: There were 297 active components in Biyuan Tongqiao granules and113 potential targets for treating rhinitis; the key components mainly including quercetin

luteolin

kaempferol

wogonin

etc; the core targets mainly including STAT3

TNF

JUN

MAPK1

IL-6

PTGS2

etc; involving multiple pathways including AGE-RAGE

IL-17

TNF

Toll-like receptor

etc; key components had strong binding activity with the core target. CONCLUSIONS: These findings have preliminarily verified the multi-component

multi-target and multi-channel mechanism of Biyuan Tongqiao granule

which laid a foundation for further study on its pharmacological mechanism and clinical application.