OBJECTIVE: To investigate the adverse drug reaction（ ADR） related to multi-trace element injection and and incompatibility in drug combination

and to discuss the prevention strategies

so as to provide reference for the clinical application of the drug and the revision of drug instructions. METHODS: CNKI

Wanfang database and VIP database were retrieved

the retrieval time was from 2007 to 2020. Literature with ADR related to multi-trace element injection and incompatibility in drug combination were extracted and analyzed. RESULTS: A total of 53 relevant literature were retrieved

including 8 literature with ADR induced by multi-trace element injection（ 1 for multiple case report

7 for case report）

and 45 literature with incompatibility of drug combination. All ADR were administered by intravenous drip. Except for one case with fructose injection as the solvent and the high concentration of multi-trace element injection

the rest of the patients were administered in accordance with the normal usage and dosage specified in the drug instructions

and the drip rate also met the requirements. In multiple case reports

ADR induced by multitrace element injection occurred about 15 min after the start of the infusion. In 9 case reports

6 cases（ 66. 67%） of ADR occurred 1 to 6 h after administration. The clinical manifestations of ADR included localized pain in the blood vessels

streak-like invagination

occlusion and pain in the surrounding skin

redness

swelling

pain and stiffness at the infusion site

phlebitis

infusion reaction and skin necrosis. The prognosis of all ADR was basically good

and no severe ADR or death cases were found. There were contraindications in the compatibility of multi-trace element injection（ Ⅱ） and a variety of drugs. CONCLUSIONS: The incidence of ADR for multi-trace element injection is not high

mainly for phlebitis. The occurrence of ADR and contraindications is related to many factors such as solvent selection

infusion speed

infusion sequence and medication monitoring. In clinical application

the usage

dosage and precautions in the drug instructions should be strictly followed

and the drug should be infused individually and slowly as far as possible

and medication monitoring should be strengthened to ensure medication safety. At present

the reports on ADR and incompatibility induced by multi-trace element injection are mostly from front-line clinical nursing staff

and the material basis and mechanism of action still need to be further studied by pharmaceutical professionals.