OBJECTIVE: To investigate the application of coenzyme complex for injection in an infectious disease hospital（ hereinafter referred to as "this hospital"）

and to discuss the necessity of key monitoring of adjuvant drugs.METHODS: A total of 2 065 discharged patients who received coenzyme complex for injection in this hospital from2019 to 2020 were selected

among which 300 cases（ 15%） were randomly selected for review. Statistical analysis was performed on patients ’ department distribution

indications

usage and dosage

contraindications

compatibility contraindications and the number of combined application of adjuvant drugs. RESULTS: Coenzyme complex for injection was widely used in the medical institution. Among the 300 patients

109 cases had irrational drug application（ 36. 33%）

among which 97 cases were off-label application of adjuvant drugs for liver disease. 18 kinds of incompatibility contraindication

6 cases of off-label long treatment course（ > 30 d）

and 2 cases of contraindication.CONCLUSIONS: There are many irrational application of coenzyme complex for injection as adjuvant drugs for liver disease

and it is necessary to strengthen the monitoring.