OBJECTIVE: To systematically evaluate the intervention effects of Xinshenghua granules on mifepristone combined with misoprostol for early medical abortion

so as to provide evidence-based reference for clinical early medical abortion. METHODS: The Cochrane Library

Pub Med

EMBase

CNKI

CBM

Wanfang database and VIP database were retrieved to collect the randomized controlled trial of Xinshenghua granules（ study group） and blank group（ control group） on intervention of mifepristone combined with misoprostol in early medical abortion

the retrieval time was from the establishment of the database to Mar. 2020. Quality of the included literature was evaluated by using the criteria in the Cochrane Handbook guidelines

while Meta-analysis was performed on the included literature by using Rev Man 5. 3 software. RESULTS: Totally 15 literature were collected

including 2 513 patients（ 1 272 patients in the study group and1 241 patients in the control group）. Meta-analysis showed that

compared with the control group

the treatment regimen in the study group significantly increased patients’ complete abortion rate（ RR = 1. 14

95% CI = 1. 11-1. 18

P < 0. 00001）

the normal rate of vaginal bleeding time（ ≤7 d）（ RR = 2. 19

95% CI = 1. 34-3. 56

P = 0. 002） and normal rate of vaginal bleeding volume（ less than or equal to normal menstrual volume）（ RR = 1. 37

95% CI = 1. 30-1. 44

P < 0. 00001）

shortened the duration of vaginal bleeding（ WMD =-4. 24

95% CI =-4. 48--4. 00

P < 0. 000 01）

menstrual rehydration time（ WMD =-3. 44

95% CI =-4. 22--2. 65

P < 0. 000 01） and the expulsion time of gestational sac（ WMD =-2. 48

95% CI =-2. 70--2. 25

P < 0. 000 01）

the differences were statistically significant.CONCLUSIONS: Xinshenghua granules can effectively improve the effect of early medical abortion of mifepristone combined with misoprostol

increase the rate of complete abortion

shorten the vaginal bleeding time

the menstrual rehydration time and the expulsion time of gestational sac

and reduce the amount of vaginal bleeding. In the future

multi-center

large-sample randomized controlled trials with higher quality and more complete methodology are needed to further verify the intervention effect of Xinshenghua granules on early medical abortion.