OBJECTIVE: To probe into the effects of high-dose atorvastatin combined with alteplase on serum inflammatory factors and neurological function in patients with acute cerebral infarction. METHODS: Totally 196 patients with acute cerebral infarction admitted into Wuming Hospital of Guangxi Medical University from Mar. 2017 to Mar. 2021 were extracted to be divided into the observation group and the control group via the random number table.Ninety-eight patients in the observation group were treated with high-dose atorvastatin combined with alteplase

and 98 patients in the control group received high-dose atorvastatin combined with urokinase. Clinical efficacy

national institutes of health stroke scale（ NIHSS） score

activity of daily living（ ADL） score

total cholesterol（ TC）

low density

lipoprotein cholesterol（ LDL-C）

triglyceride（ TG） and high-density lipoprotein cholesterol（ HDL-C）levels

serum tumor necrosis factor-α（ TNF-α）

high sensitivity C-reactive protein（ hs-CRP） and matrix metalloproteinase-9（ MMP-9） levels before and after treatment in two groups were observed. RESULTS: The total effective rate of the observation group was 95. 92%（ 94/98）

and the total effective rate of the control group was91. 84%（ 90/98）

with no statistically significant difference between two groups（ P > 0. 05）. After 42 d of treatment

the NIHSS scores of two groups were significantly lower than those before treatment

and the observation group was significantly lower; the ADL score was significantly higher than those before treatment

and the observation group was significantly higher

the differences were statistically significant（ P < 0. 05）. After 42 d of treatment

the levels of TC

TG and LDL-C of two groups were significantly lower than those of the same group before treatment

and the levels of HDL-C were significantly higher than those of the same group before treatment

and the differences were statistically significant（ P < 0. 05）. After 42 d of treatment

there was no significant difference in levels of TC

TG

LDL-C and HDL-C between two groups（ P > 0. 05）. After 42 d of treatment

the levels of TNF-α

hs-CRP and MMP-9 in two groups were significantly lower than those before treatment

and the reduction in the observation group was significantly greater than that in the control group

the differences were statistically significant（ P < 0. 05）.CONCLUSIONS: Compared with high-dose atorvastatin combined with urokinase

high-dose atorvastatin combined with alteplase has advantages in improving neurological damage

restoring the ability of daily life and reducing the inflammation in patients with acute cerebral infarction.