OBJECTIVE: To probe into the effects of bisoprolol combined with propafenone on the expression of adiponectin（ APN） and nuclear factor κB（ NF-κB） in patients with arrhythmia of coronary heart disease. METHODS:Totally 96 patients with arrhythmia of coronary heart disease admitted into Guang’an Hospital of West China Hospital of Sichuan University from Apr. 2019 to Aug. 2020 were selected and divided into propafenone group and combined treatment group via random number table

with 48 cases in each group. Patients in propafenone group were treated with propafenone

patients in combined treatment group were given bisoprolol combined with propafenone. The total cholesterol（ TC）

triglycerides（ TG）

high-density lipoprotein cholesterol（ HDL-C） and low-density lipoprotein cholesterol（ LDL-C） levels were detected; the left ventricular end-diastolic diameter（ LVEDD）

left ventricular endsystolic diameter（ LVESD） and left ventricular ejection fraction（ LVEF） were measured by color doppler diasonograph; 24 h electrocardiogram was used to record the number of premature atrial contraction and ventricular premature contraction; the APN and NF-κB levels were measured. RESULTS: The TC

TG and LDL-C levels of patients in combined treatment group were significantly lower than those in propafenone group

and the HDL-C level was significantly higher than that of propafenone group

with statistically significant differences（ P < 0. 05）. The LVEDD and LVEF of patients in combined treatment group were significantly higher than those in propafenone group after treatment

and the LVESD level was significantly lower than that of propafenone group

with statistically significant differences（ P < 0. 05）. The number of premature atrial contraction and ventricular premature contraction of patients in combined treatment group were significantly lower than those in propafenone group after treatment

and the APN and NF-κB levels were significantly lower than those of propafenone group

with statistically significant differences（ P < 0. 05）. The total effective rate of patients in combined treatment group were 95. 83%（ 46/48）

which was significantly higher than that of propafenone group（ 75. 00%

36/48）

with statistically significant difference（ P <0. 05）. CONCLUSIONS: The application of bisoprolol combined with propafenone can effectively regulate blood lipid level in patients with arrhythmia of coronary heart disease

improve cardiac function and arrhythmia

which has significant efficacy.