OBJECTIVE: To probe into the efficacy of Jiuwei Zhenxin Granules combined with sodium valproate sustained release tablets in the treatment of bipolar affective disorder in maintenance period. METHODS: Totally 92 patients with bipolar affective disorder admitted into Ningxia Ning’an Hospital from Jun. 2017 to Jun. 2020 were selected and divided into control group and research group via random number table

with 46 cases in each group. The control group was treated with sodium valproate sustained release tablets

while the research group was given Jiuwei Zhenxin Granules based on the control group

both groups were treated for 2 months. The clinical efficacy of two groups were observed

polysomnogram was used to detect the sleep quality

trail making test（ TMT） was used to evaluate the cognitive function

generic quality of life inventory（ GQL-LI） was used to assess the life quality; and adverse drug reactions during treatment were recorded. RESULTS: The clinical total effective rate of research group was 91. 30%（ 42/46）

which was significantly higher than that of the control group（ 73. 91%

34/46）

with statistically significant difference（ P < 0. 05）. The sleep efficiency of patients in both groups were significantly higher than those of before treatment

the total sleep time and rapid eye movement sleep time of patients in both groups were significantly longer than those of before treatment

the sleep latency and waking time of patients in both groups were significantly shorter than those of before treatment; patients in the research group had significantly higher sleep efficiency

significantly longer total sleep time and rapid eye movement sleep sleep time

and significantly shorter sleep latency and waking time than those in the control group

with statistically significant differences（ P < 0. 05）. The TMT-A and TMT-B times of both groups after treatment were significantly shorter and the GQL-LI scores were significantly higher than those of before treatment; patients in the research group had significantly shorter TMT-A and TMT-B times and significantly higher GQL-LI scores than those in the control group

with statistically significant differences（ P < 0. 05）.The incidences of adverse drug reactions of control group and research group were respectively 19. 57%（ 9/46） and8. 70%（ 4/46）

with no statistically significant difference（ P > 0. 05）. CONCLUSIONS: The clinical effect of Jiuwei Zhenxin Granules combined with sodium valproate sustained release tablets in the treatment of bipolar affective disorder in maintenance period is remarkable

which can improve patients’ sleep quality

prolong nighttime sleep time and promote patients’ cognitive function

with high safety

and can provide a reference scheme for clinical treatment of bipolar affective disorder in maintenance phase.