OBJECTIVE: To probe into the therapeutic effect of gamma-globulin combined with dipyridamole in the treatment of atypical kawasaki disease in children. METHODS: Totally 64 children with atypical kawasaki disease admitted into Beijing Haidian Hospital from Jan. 2017 to Jan. 2020 were selected and divided into control group and observation group via completely random method

with 32 cases in each group. Both groups were given symptomatic treatment on admission; the control group was given gamma-globulin on that basis; the observation group was given dipyridamole based on the control group. Children in the two groups were compared in terms of the disappearance time of symptoms and signs（ fever

mucous membrane congestion

swollen cervical lymph nodes

swollen hands and feet）

the white blood cell count（ WBC）

platelet count（ PLT）

C-reactive protein（ CRP） and calcitoninogen（ PCT） levels were measured

and the therapeutic effect and adverse drug reactions were observed. RESULTS: The fever remission

mucosal congestion disappeared

cervical lymph node enlargement subsided

hand and foot swelling subsided of children in the observation group were significantly shorter than those in the control group

with statistically significant differences（ P < 0. 05）. The WBC and PLT levels of children in the observation group were significantly lower than those in the control group

the CRP and PCT levels were significantly lower in the observation group than the control group after treatment

with statistically significant differences（ P < 0. 05）. The total effective rate of children in the observation group was 93. 75%（ 30/32）

which was significantly higher than that of the control group（ 71. 88%

23/32）

with statistically significant difference（ P < 0. 05）. The incidences of adverse drug reactions of children in observation group and control group were respectively 28. 13%（ 9/32） and 34. 38%（ 11/32）

with no statistically significant difference（ P > 0. 05）. CONCLUSIONS: The efficacy of gamma-globulin combined with dipyridamole in the treatment of atypical kawasaki disease is remarkable

which helps to control the inflammatory reaction and promote the recovery of children’s health.