OBJECTIVE: To probe into the mechanism of Xiaoer Qingrehuaji powder in the treatment of acute infantile convulsion. METHODS: Network pharmacology approach was adopted to construct biomolecular network related to Xiaoer Qingrehuaji powder and conduct bioinformatics annotation and analysis. Molecular docking on compounds with key targets in Xiaoer Qingrehuaji powder was performed with the help of Auto Dock Vina software. RESULTS: A total of 122 potential active compounds

1 255 predicted targets and 1 023 targets related to pediatric acute convulsion were obtained from Xiaoer Qingrehuaji powder. Totally 304 potential targets for efficacy were derived from the "compound-target-disease"network

which had involved biological process including regulation of membrane potential

response to antibacterial drugs and regulation of chemical synaptic transmission; cellular components including ion channel complexes

transmembrane transport protein complexes and neuronal cell bodies; molecular functions including gated channel activity

ion channel activity and passive transmembrane transport protein activity; signal pathways including neuroactive ligand-receptor interaction

Alzheimer’s disease

MAPK and cAMP. Results of molecular docking showed good binding ability（ all Affinity <-5 kcal/mol） between 36 compounds and their corresponding key targets. CONCLUSIONS: The mechanism of Xiaoer Qingrehuaji powder in the treatment of pediatric acute convulsion may be related to biological function including regulation of membrane potential

neurological function regulation

neuroactive ligand-receptor interaction and inflammatory response

the targets of DRD2

OPRK1

GABBR2 and PIK3 CA can be focused on.