OBJECTIVE: To investigate the clinical use of commonly used immunosuppressant in pediatrics in Guangzhou Women and Children ’s Medical Center（ hereinafter referred to as "our hospital "）

so as to provide reference for the standardized use of immunosuppressant in children. METHODS: A total of 3 318 pediatric prescriptions with tacrolimus

cyclosporine

mortimecofenate and sirolimus in our hospital from 2019 to 2020 were randomly selected by retrospective investigation. According to the relevant guidelines

consensus and other evidencebased evidence

the use of immunosuppressant in the prescription was specially reviewed. RESULTS: Among 3 318 prescriptions of commonly used immunosuppressant in pediatrics

138 prescriptions had irrational drug use

with irrational rate of 4. 2%. The irrational types were respectively irrational drug combination（ 51 prescriptions

accounting for 37. 0% of unreasonable prescriptions）

improper usage and dosage（ 35 prescriptions

accounting for 25. 4% of unreasonable prescriptions）

and without indications or off-label indications（ 24 prescriptions

accounting for 17. 4% of unreasonable prescriptions）. CONCLUSIONS: There are still some irrational use of immunosuppressant in children in our hospital. It is necessary to strengthen the drug use education among clinicians

nurses and patients

pay attention to the standardized use and concentration monitoring of immunosuppressant

and continuously improve the prescription review system in our hospital to promote the rational and standardized use of immunosuppressant in clinic.