OBJECTIVE: To investigate the discharge prescription with drugs in the Tenth People ’s Hospital Affiliated to Tongji University（ hereinafter referred to as "our hospital "）

to identify problems and study countermeasures

so as to promote the rational drug application for discharged patients. METHODS: Totally 6 000 discharge prescription with drugs in our hospital from Mar. 2019 to Feb. 2020 were extracted for prescription review

the irrational drug application and potential drug interaction were analyzed. RESULTS: Among the 6 000 discharge prescription

there were 105 irrational prescriptions

accounted for 1. 75% of the total prescriptions; there were 237 prescriptions with potential drug interactions

accounting for 3. 95% of the total prescriptions. The main problems were unreasonable dosage

inappropriate usage

super-therapeutic use

improper drug combination and potential drug interaction. CONCLUSIONS: Dispensing pharmacists and clinical pharmacists should strengthen cooperation

and dispensing pharmacists should timely intervene the prescriptions to reduce the occurrence of irrational prescriptions;clinical pharmacists should carry out discharge medication education to ensure safe and effective medication for discharged patients.