OBJECTIVE: To probe into the clinical efficacy of traditional Chinese medicine for aerosol inhalation combined with retention enema in the treatment of sepsis（ syndrome of excessive heat of qifen） caused by multidrugresistant organism（ MDRO）. METHODS: Totally 90 patients with sepsis（ syndrome of excessive heat of qifen） admitted into the ICU department of Jining Hospital of Traditional Chinese Medicine from Jun. 2019 to May 2020 were selected for prospective study

these patients were divided into research group and control group via random number table

with 45 cases in each group. Both groups had received standard treatment according to the "Guidelines for the Treatment of Severe Sepsis/Septic Shock in China"

the research group was given bluestone mixture for nebulized inhalation combined with modified Baihu decoction for retention enema

7 days were set as 1 course of treatment

both groups were treated for1 course

and the efficacy was counted at the end of treatment course. Changes of traditional Chinese medicine（ TCM）syndrome integral

acute physiology and chronic health evaluation Ⅱ（ APACHEⅡ） and serum procalcitonin（ PCT） and lactate（ Lac） contents were compared between two groups before and after treatment

the safety profile of the two groups was recorded. RESULTS: After rank-sum test

the TCM syndrome efficacy grading of patients in the research group was better than that of the control group

the total effective rate of patients in the research group was 95. 56%（ 43/45）

which was significantly higher than that of the control group（ 82. 22%

37/45）

with statistically significant difference（ P< 0. 05）. After treatment

the TCM syndrome integral and APACHEⅡ scores of both groups had been significantly decreased

the serum PCT and Lac levels were significantly lower than those of before treatment

and the above scores and serum index levels were significantly lower in the research group than those in the control group

with statistically significant differences（ P < 0. 05）. Both groups were in a good safety profile. CONCLUSIONS: The efficacy of traditional Chinese medicine for aerosol inhalation combined with retention enema in the treatment of sepsis（ syndrome of excessive heat of qifen） caused by MDRO is remarkable

which can effectively improve the clinical symptoms and prognosis of patients

reduce serum PCT and Lac levels

with good treatment safety.