OBJECTIVE: To probe into the clinical efficacy of thrombin lyophilized powder combined with omeprazole in the treatment of peptic ulcer with hemorrhage. METHODS: Totally 100 patients with peptic ulcer with hemorrhage admitted into Beijing Huairou Hospital from Mar. 2016 to Mar. 2020 were extracted to be divided into the control group and the observation group according to the random number table method. Fifty patients in the control group were treated with omeprazole

while 50 patients in the observation group received thrombin lyophilized powder combined with omeprazole. Both groups were treated for 3 to 5 d. The clinical efficacy was evaluated after treatment. Hemostasis time

length of stay and recurrence rate

prothrombin time（ PT）

activated partial thromboplastin time（ APTT）

thrombin time（ TT）

platelet pressure product（ PCT）

platelet count（ BPC） and platelet volume（ MPV） levels of two groups before and after treatment were compared. The incidence of adverse drug reactions during treatment in both groups were observed. RESULTS: The total efficiency of ulcer healing and hemostatic efficiency in the observation group were higher than those in the control group

and the difference was statistically significant（ P < 0. 05）. The hemostasis time and length of stay in the observation group were significantly shorter than those in the control group

and the recurrence rate was significantly lower than that in the control group

with statistically significant difference（ P < 0. 05）. After treatment

PT

APTT and TT in two groups were significantly shorter than those before treatment; and PT

APTT and TT in the observation group were significantly shorter than those in the control group after treatment

the differences were statistically significant（ P < 0. 05）. After treatment

PCT and BPC in two groups were significantly higher than those before treatment

and MPV was significantly lower than those before treatment; meanwhile

PCT and BPC in the observation group were significantly higher than those in the control group after treatment

and MPV was significantly lower than that in the control group

with statistically significant differences（ P < 0. 05）. During the treatment

the incidence of adverse drug reactions in the observation group was 12. 00%（ 6/50）

compared with 10. 00%（ 5/50） in the control group

and the difference was not statistically significant（ χ2= 0. 102

P = 0. 749）. CONCLUSIONS: The clinical efficacy of thrombin lyophilized powder combined with omeprazole in the treatment of peptic ulcer with hemorrhage is significant

while can shorten the hemostasis time and length of stay

reduce the recurrence rate

improve the coagulation function and platelet parameters

and has higher safety.