OBJECTIVE: To probe into the possible factors that influencing the allergic reactions after intravenous infusion of cytotoxic drugs in summer

and to provide the protocol reference for retrospective investigation to avoid more cases of allergic reactions induced by intravenous infusion of cytotoxic drugs. METHODS: Combined with the investigation of cytotoxic drugs that induced multiple allergic reactions in the oncology department of a GradeⅢ

level A hospital in Beijing from Jun. to Jul. 2019

the possible causes of infusion reactions were investigated according to the storage and use of the same batch of drugs and the drugs involved in the medical order. RESULTS:Through the investigation of supply

storage and configuration of the drug

the allergic reactions ruled out the possibility of infusion reactions. However

after comprehensive analysis

it is found that

（ 1） the finished infusion solution was exposed to the outdoor summer environment when transported to the department

which could damage the stability of the quality of the infusion solution;（ 2） in the peak of summer

the immune function of patients might be abnormaldue to the higher temperature and humidity environment. Therefore

the higher temperature and humidity environment was the main cause of allergic reactions after drug infusion. CONCLUSIONS: In summer

the incidence of allergic reactions to antineoplastic drugs will increase. Therefore

temperature-sensitive cytotoxic drugs should be dispensed on the spot

and the humidity and temperature of the ward should be controlled to enhance patient monitoring and care.