OBJECTIVE: To investigate the status of detection and drug resistance of Mycoplasma in outpatients with genitourinary system infection in Henan Provincial Hospital( hereinafter referred to as "our hospital"

so as to provide theoretical basis for clinical diagnosis and treatment. METHODS: Retrospective statistical analysis was carried out on the culture and drug sensitive results of Mycoplasma test in patients with genitourinary system infection in our hospital in 2018. Mycoplasma culture and in vitro drug sensitivity test results of 850 outpatients with genitourinary system infection in our hospital in 2018 were analyzed retrospectively. RESULTS: Among the 850 patients

523 cases were positive for Mycoplasma

with a Mycoplasma carriage rate of 61. 53%

of which the single positive rates for Ureaplasma urealyticum（ UU） and Mycoplasma hominis（ MH） were respectively 49. 18%（ 418 cases） and 2. 12%（ 18 cases）

and the rate of mixed infections was 10. 24%（ 87 cases）. Mycoplasma was more sensitive to doxycycline

minocycline hydrochloride

tetracycline

coxsamine and clarithromycin

with sensitivity rates of 86. 42%（ 452 cases）

83. 37%（ 436 cases）

80. 69%（ 422 cases）

70. 94%（ 371 cases） and 70. 75%（ 370 cases）

respectively. Mycoplasma had high resistance rates to ciprofloxacin

azithromycin

roxithromycin

sparfloxacin and levofloxacin

with resistance rates of 81. 64%（ 427 cases）

71. 32%（ 373 cases）

66. 92%（ 350 cases）

53. 35%（ 279 cases） and 48. 95%（ 256 cases）

respectively. Mycoplasma resistance rates were generally higher in UU-infected patients with UU counts ≥104 than in those with UU counts < 104. Mycoplasma resistance rates were the highest in those with mixed infections of the two kinds of Mycoplasma

followed by those with MH infection

and lower in those with UU infection.CONCLUSIONS: Mycoplasma carriage rate among outpatients with genitourinary infection was high and dominated by UU infection

followed by mixed UU and MH infection. Doxycycline

minocycline hydrochloride and tetracycline are recommended for empirical clinical treatment

while Mycoplasma culture and drug sensitivity tests need to be performed on suspected infected patients to reduce the emergence of drug-resistant strains.