OBJECTIVE: To evaluate the clinical evidence of Huoxiang Zhengqi oral preparation in the treatment of gastrointestinal dysfunction based on evidence-based pharmacy

so as to provide evidence-based evidence for clinical treatment and decision makers. METHODS: Systematic review/Meta-analysis on Huoxiang Zhengqi oral preparation in the treatment of gastrointestinal dysfunction（ the Huoxiang Zhengqi oral preparation group was given Huoxiang Zhengqi oral preparation alone or in combination with other drugs

while the control group was given placebo or other positive control drugs） were collected after retrieving PubMed

the Cochrane Library

SinoMed

CNKI and Wanfang database

two researchers performed comprehensive analysis after literature screening

data extracting and quality evaluation according to the inclusion and exclusion criteria. RESULTS: Totally 4 pieces of systematic review/Meta-anlysis were involved

with the average score of assessment of multiple systematic reviews（ AMSTAR） was 6. 3 points. Results of analysis indicated that the Huoxiang Zhengqi oral preparation can significantly improve the clinical effective rate in the treatment of gastrointestinal cold

which also had significantly better effect than western medicine in improving chills

fever and bowel diarrhea; Huoxiang Zhengqi oral preparation combined with conventional treatment or combined with norfloxacin can significantly improve the total effective rate in the treatment of acute gastroenteritis

which had significantly better effect in improving fever and vomiting than that of conventional treatment or norfloxacin alone

the combined application of Huoxiang Zhengqi oral preparation and norfloxacin can significantly improve the symptoms of abdominal pain and diarrhea; the effectiveness of Huoxiang Zhengqi oral preparation on functional dyspepsia was equivalent to domperidone（ or combined with gefaxacin）.Due to the limited safety data

the results show that compared with the control group

the incidence of adverse drug reactions in the Huoxiang Zhengqi oral preparation group did not increase significantly. CONCLUSIONS: Huoxiang Zhengqi oral preparation has good effectiveness and safety in the treatment of gastrointestinal dysfunction

especially in combination with western conventional therapy.While the above result still need to be validated by additional high-quality clinical researches.