OBJECTIVE: To investigate the release characteristic of meropenem bone cement in vitro

so as to provide reference for clinical application. METHODS: Meropenem was added into bone cement with a mould to make bone cement implant containing meropenem 10%（ W/W） and immersed in a modified simulated body fluid at 37 ℃ . The sampling time points were set by isometric leaching method

the concentration of leaching solution was measured by ultra performance liquid chromatography-tandem mass spectrometry to observe the release pattern of meropenem bone cement implant. RESULTS: The peak value of drug-release of meropenem bone cement grain occurred at 2 h

followed by gradual decrease of drug-releasing rate

and the cumulative releasing amount at 19 h had reached 92. 37% of the overall releasing amount

the cumulative releasing rate reached 6. 00% at 24 d. The in vitro release characteristic fitted the Weibull equation mold（ r = 0. 915 1）. CONCLUSIONS: The meropenem bone cement have delayed release characteristics

which mainly concentrates on the first 72 h

with little release in the later period. The result of this study can provide a reference for the clinical application of meropenem in the treatment of bone infections.