OBJECTIVE: To probe into the clinical efficacy of Tangmaikang granules combined with cilostazol in the treatment of diabetic peripheral neuropathy（ DPN）. METHODS: Totally 80 patients with DPN admitted into Foshan Hospital of Traditional Chinese Medicine from Apr. 2018 to Dec. 2019 were extracted to be divided into the control group（ treated with cilostazol） and the observation group（ treated with Tangmaikang granules on the basis of the control group） via the random number table

with 40 cases in each group. The clinical efficacy

blood glucose index

serum index

nerve conduction velocity and the incidence of adverse drug reactions of two groups were observed. RESULTS:After treatment of 3 months

the levels of glycosylated hemoglobin（ HbA1 c）

fasting blood glucose and 2 h postprandial blood glucose（ 2 h PG） in both groups were significantly lower than those before treatment

and the levels of HbA1 c

fasting blood glucose and 2 h PG in the observation group were significantly lower than those in the control group

with statistically significant difference（ P<0. 05）. The total clinical effective rates of the observation group and the control group were respectively 92. 50%（ 37/40） and 72. 50%（ 29/40）

and the observation group was significantly higher than the control group

with statistically significant difference（ P<0. 05）. After treatment of 3 months

compared with before treatment

the levels of malondialdehyde（ MDA）

tumor necrosis factor（ TNF-α） and interleukin 6（ IL-6） in both groups decreased significantly

while the level of superoxide dismutase（ SOD） increased significantly; the levels of MDA

TNF-α and IL-6 in the observation group were significantly lower than those in the control group

and the level of SOD was significantly higher than that in the control group

the differences were statistically significant（ P <0. 05）. After treatment of 3 months

the motor nerve conduction velocity（ MCV）

sensory nerve conduction velocity（ SCV）

median nerve MCV and SCV in both groups were significantly higher than those before treatment

and the observation group was significantly higher than the control group

the differences were statistically significant（ P <0. 05）. The incidences of adverse drug reactions in the control group and observation group were respectively 12. 50%（ 5/40） and 17. 50%（ 7/40）

the difference was not statistically significant（ P>0. 05）. CONCLUSIONS: Tangmaikang granules combined with cilostazol in the treatment of DPN can effectively control the blood glucose in patients

improve the nerve conduction velocity with higher safety. The main mechanism of action may be related to the regulation of SOD

MDA

TNF-α and IL-6 and other cytokine levels.