OBJECTIVE: To probe into the clinical effect of Tiandan Tongluo capsules combined with probucol in the treatment of phlegm-stagnation type of senile cerebral infarction complicated with carotid atherosclerotic plaque.METHODS: Totally 102 patients with phlegm-stagnation type of senile cerebral infarction complicated with carotid atherosclerotic plaque admitted into Fengtai Hospital of Integrated Chinese and Western Medicine from Jul. 2018 to Jun. 2020 were divided into control group and research group via random number table. Both groups were given conventional therapy

on that basis

the 51 patients in control group was given probucol

while the other 51 patients in research group was given Tiandan Tongluo capsules combined with probucol

both groups were given continuous treatment for 3 months. The clinical efficacy was compared between two groups

the TCM syndrome scores were recorded before and after treatment

the changes of high and low echogenic plaques were observed by ultrasound and the plaque area was measured; the hemodynamics of common carotid artery

serum hypersensitive C-reactive protein（ hs-CRP）

D-dimer and matrix metalloproteinase 9（ MMP-9） levels of the two groups were measured before and after treatment; the incidences of adverse drug reactions in the two groups during treatment was collected. RESULTS: The total effective rate of research group was 92. 16%（ 47/51）

which was significantly higher than that of the control group（ 74. 51%

38/51）

with statistically significant difference（ P < 0. 05）. After treatment

the TCM symptom scores of both groups were significantly lower than those of before treatment

and that of the research group were significantly lower than the control group

with statistically significant differences（ P < 0. 05）. After treatment

the plaque area of patients in the research group was significantly smaller than that of the control group

the number of hypo-echoic plaques of the research group was significantly less than that of the control group

and the number of hyper-echoic plaques of the research group was significantly more than that of the control group

with statistically significant differences（ P < 0. 05）. There was no statistical significance in difference in the mid-systolic internal diameter of carotid artery between the two groups after treatment（ P>0. 05）; the end-diastolic flow velocity and peak systolic flow velocity levels of patients in the research group were significantly higher than those in the control group

and the resistance index and pulsatility index of patients in the research group were significantly lower than those in the control group

with statistically significant differences（ P<0. 05）. The serum hs-CRP

D-dimer and MMP-9 levels of patients in the research group were significantly lower than those in the control group

with statistically significant differences（ P<0. 05）. The incidences of adverse drug reactions of patients in the control group and research groups were respectively 7. 84%（ 4/51） and 3. 92%（ 2/51）

the difference was not statistically significant（ P > 0. 05）.CONCLUSIONS: The efficacy of Tiandan Tongluo capsules combined with probucol in the treatment of phlegmstagnation type of senile cerebral infarction complicated with carotid atherosclerotic plaque is remarkable

which can significantly improve hemodynamics

reduce serum hs-CRP

D-dimer and MMP-9 levels.