OBJECTIVE: To investigate the status of drug administration via stomach tube for patients with severe liver disease

so as to to provide reference for the rational drug use through feeding tubes in clinic. METHODS:Retrospective investigation method was adopted to evaluate and analyze the rationality of tube feeding administration in100 patients admitted into liver disease of intensive care unit in a medical institution in 2020. RESULTS: 100 patients of severe liver disease received tube feeding for 4 917 case-times

including 99 kinds of drugs. There were544 case-times of irrational drug use

and the irrational rate was 11. 06%

including 424 case-times of unsuitable dosage form and 120 case-times of improper drug combination. Issues mainly included the crushing of disintegrating carcinogenic and cytotoxic drugs

crushing of enteric-soluble preparations and slow-controlled release preparations by tube feeding

soft capsules by tube feeding with inaccurate dosage

drug combination of microecological drugs and antibiotics. CONCLUSIONS: There are irrational phenomenon in clinical tube feeding

appropriate intervention by clinical pharmacists with professional knowledge of pharmacy can promote the rationality of tube feeding and improve the effectiveness and safety of drug therapy.