OBJECTIVE: To investigate the application of ertapenem in inpatients of Peking University Third Hospital（ hereinafter referred to as "our hospital"）

so as to evaluate the rationality of medication and analyze the reasons. METHODS: The retrospective study method were used to obtain 300 medical records of inpatients receiving ertapenem in our hospital from Apr. 2018 to Mar. 2019. Based on the Guidelines for Clinical Application of Antibiotics（ 2015 Edition）

relevant guidelines and expert consensus

statistical analysis was performed on indications

microbiological examination submission

usage and dosage

and drug combination. Rationality of medication and its related influencing factors were evaluated. RESULTS: Among the 300 inpatients receiving ertampenem

42 cases（ 14. 00%） received perioperative prophylactic drugs. There were 258 cases（ 86. 00%） of therapeutic drugs

among which 208 cases received microbiological examination

and 111 cases（ 53. 37% of the total number of microbiological examination） were submitted for microbiological examination before therapeutic drugs. There were 238 cases of rational drug application

with the rational rate of 79. 33%. The main manifestations of irrational drug application were high starting point of antibiotics

long duration of treatment and inappropriate drug combination. Factors influencing the application rationality of ertapenem included the clinical pharmacist intervention（ P < 0. 05） and department types（ P< 0. 001）. CONCLUSIONS: The application of ertapenem in our hospital is still irrational

intervention management needs to be further strengthened to promote the rational application of ertapenem in clinic.