胆宁片治疗非酒精性脂肪性肝病临床疗效的系统评价

丁春梅; 王卓媛; 白换换; 侯立新; 苟小军; 徐美玲

doi:10.14009/j.issn.1672-2124.2021.04.018

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胆宁片治疗非酒精性脂肪性肝病临床疗效的系统评价

用药评价 | 更新时间：2022-10-08

- 胆宁片治疗非酒精性脂肪性肝病临床疗效的系统评价
- Systematic Reviewof Clinical Efficacy of Danning Tablet in the Treatment of Non-Alcoholic Fatty Liver Disease
- 中国医院用药评价与分析 2021年21卷第4期页码：459-463
- 作者机构：
  
  1. 上海市浦东新区迎博社区卫生服务中心全科医学科
  2. 陕西中医药大学药学院
  3. 上海市宝山区中西医结合医院中心实验室
  4. 重庆市急救医疗中心重庆大学附属中心医院药剂科
- 作者简介：
- 基金信息：
  
  国家自然科学基金面上项目（No.82074083）
- DOI：10.14009/j.issn.1672-2124.2021.04.018
  中图分类号： R575.5
- 纸质出版日期：2021，
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[1]丁春梅,王卓媛,白换换,侯立新,苟小军,徐美玲.胆宁片治疗非酒精性脂肪性肝病临床疗效的系统评价[J].中国医院用药评价与分析,2021,21(04):459-463.

DING Chunmei, WANG Zhuoyuan, BAI Huanhuan, et al. Systematic Reviewof Clinical Efficacy of Danning Tablet in the Treatment of Non-Alcoholic Fatty Liver Disease[J]. 2021,21(4):459-463.
[1]丁春梅,王卓媛,白换换,侯立新,苟小军,徐美玲.胆宁片治疗非酒精性脂肪性肝病临床疗效的系统评价[J].中国医院用药评价与分析,2021,21(04):459-463. DOI： 10.14009/j.issn.1672-2124.2021.04.018.

DING Chunmei, WANG Zhuoyuan, BAI Huanhuan, et al. Systematic Reviewof Clinical Efficacy of Danning Tablet in the Treatment of Non-Alcoholic Fatty Liver Disease[J]. 2021,21(4):459-463. DOI： 10.14009/j.issn.1672-2124.2021.04.018.

摘要

目的:系统评价胆宁片治疗非酒精性脂肪性肝病的临床疗效。方法:通过计算机检索Pub Med、Cochrane图书馆、中国知网、万方数据库和维普数据库

检索建库至2020年11月发表的胆宁片治疗非酒精性脂肪性肝病的随机对照试验文献（研究组患者以胆宁片联合西药进行治疗

对照组患者单独使用西药治疗）

采用纽卡斯尔-渥太华量表（Newcastle-Ottawa scale

NOS）进行文献质量的评价

提取肝功能指标[丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）]、血脂指标[甘油三酯（TG）、总胆固醇（TC）]

参数

应用Rev Man 5.3软件进行荟萃分析（Meta分析）

使用Stata 15.0软件进行敏感性分析及发表偏倚检测。结果:共纳入的10篇随机对照试验文献

总病例数为895例。Meta分析结果显示

研究组患者的总有效率明显高于对照组（OR=6.07

95%CI=3.63～10.15

Z=6.89

0.000 01

=0%

50%）

研究组患者的ALT（MD=-8.38

95%CI=-9.56～-7.21

Z=13.98

0.00001

=11%

50%）、AST（MD=-9.77

95%CI=-10.93～-8.61

Z=16.51

0.000 01

=0%

50%）、TG（MD=-0.48

95%CI=-0.53～-0.43

Z=19.30

0.000 01

=45%

50%）和TC（MD=-0.73

95%CI=-0.81～-0.65

Z=17.71

0.000 01

=1%

50%）等指标水平均明显优于对照组

上述差异均有统计学意义。结论:胆宁片与西药联合治疗非酒精性脂肪性肝病的总有效率高于单独使用西药治疗

且在降低ALT、AST、TG和TC方面的效果明显优于单独使用西药治疗。

Abstract

OBJECTIVE: To systematically evaluate the clinical efficacy of Danning tablets in the treatment of nonalcoholic fatty liver disease. METHODS: PubMed

the Cochrane Library

CNKI

Wanfang database and VIP database were retrieved to collect the randomized controlled trial of Danning tablets in the treatment of non-alcoholic fatty liver disease（ the study group was treated with Danning tablets combined with western medicine

while the control group received western medicine alone）

the retrieval time was from the establishment of the database to Nov. 2020.Newcastle-Ottawa scale（ NOS） was used to evaluate the quality of the literature. The parameters of liver function indexes[alanine aminotransferase（ ALT）

aspartate aminotransferase（ AST） ]

blood lipid indexes[triglycerides（ TG）

total cholesterol（ TC） ]

were extracted

and Meta-analysis was performed with RevMan 5. 3 software. Stata 15. 0 software was used for sensitivity analysis and publication bias detection. RESULTS: A total of 10 randomized controlled trials were included

with 895 cases. Meta-analysis showed that the total effective rate of the study group was significantly higher than that in the control group（ OR = 6. 07

95% CI = 3. 63-10. 15

Z = 6. 89

0. 000 01

= 0%

50%）; ALT（ MD =-8. 38

95% CI =-9. 56--7. 21

Z = 13. 98

0. 000 01

= 11%

50%）

AST（ MD =-9. 77

95% CI =-10. 93--8. 61

Z = 16. 51

0. 000 01

= 0%

50%）

TG（ MD =-0. 48

95% CI =-0. 53--0. 43

Z = 19. 30

0. 000 01

= 45%

50%）

TC（ MD =-0. 73

95% CI =-0. 81--0. 65

Z = 17. 71

0. 000 01

= 1%

50%） and other indexes in the study group were significantly better than those in the control group

and the differences were statistically significant. CONCLUSIONS: The total effective rate of Danning tablets combined with western medicine in the treatment of non-alcoholic fatty liver disease is higher than that of western medicine alone

and its effect in reducing ALT

AST

TG and TC is significantly better than that of western medicine alone.

关键词

胆宁片非酒精性脂肪性肝病Meta分析

Keywords

Danning tabletsNon-alcoholic fatty liver diseaseMeta-analysis

references

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