OBJECTIVE: To preliminarily investigate the mechanism of Semen cuscutae pills of Lingzhu in the treatment of renal proteinuria based on network pharmacology. METHODS: TCMSP was used for getting the active ingredients and targets of components of Semen cuscutae pills of Lingzhu

the targets related with renal proteinuria were obtained by searching OMIM and Gene Cards databases

Venn analysis of the obtained data sets was carried out to acquire the target of Semen cuscutae pills of Lingzhu on renal proteinuria. Visualized processing was conducted by Cytoscape software after the construction of protein interaction network by String database. Gene ontology（ GO） function enrichment analysis and Kyoto encyclopedia of genes and genomes（ KEGG） pathway enrichment analysis were carried out based on DAVID database. RESULTS: There were 138 kinds of active ingredient and 75 concurrent targets of Semen cuscutae pills of Lingzhu acting on renal proteinuria. 93 items was inquired from GO function enrichment analysis;119 items were inquired from KEGG function enrichment analysis

including tumor signal pathway

process of cell apoptosis

tumor necrosis factor signal pathway

etc. CONCLUSIONS: The mechanism of Semen cuscutae pills of Lingzhu in the treatment of renal proteinuria has been predicted through network pharmacology

which could provide reference for further study.