OBJECTIVE: To explore the clinical efficacy of ALA-PDT

Bacillus Calmette-Guerin（ BCG）polysaccharide nucleic acid injection combined with Thymosin enteric-coated tablets in the treatment of condyloma acuminatum. METHODS: Totally 174 patients with condyloma acuminatum admitted into Zhuhai People’s Hospital from Jul. 2017 to Jul. 2020 were extracted to be divided into the thymosin treatment group and the drug combination group via the random number table

with 87 cases in each group. The thymosin treatment group was treated with Thymosin enteric-coated tablets

while the drug combination group was given ALA-PDT

BCG polysaccharide nucleic acid injection combined with Thymosin enteric-coated tablets. Levels of tumor necrosis factor α（ TNF-α）

lymphotactin（ LTN）

substance P（ SP）

T lymphocyte subsets and transforming growth factor β1（ TGF-β1） in both groups were detected. The treatment effect and incidence of adverse drug reactions were observed and statistically analyzed. RESULTS: After treatment

compared with the thymosin treatment group

the level of LTN of the drug combination group increase significantly

the level of SP decreased significantly

the levels of CD3+and CD4+increased significantly

the levels of CD8+decreased significantly

the level of TGF-β1 increased significantly and the level of TNF-α decreased significantly

with statistically significant differences（ P < 0. 05）. The total effective rate of the drug combination group was 96. 15%（ 75/78）

compared with 87. 18%（ 68/78） of the thymopeptide treatment group

the difference was statistically significant（ P < 0. 05）. The incidence of adverse drug reactions in the thymosin treatment group and the drug combination group group was respectively 7. 69%（ 6/78） and 12. 82%（ 10/78）

with no statistically significant difference（ P > 0. 05）. CONCLUSIONS: The efficacy of ALA-PDT

BCG polysaccharide nucleic acid injection combined with Thymosin enteric-coated tablets in the treatment of condyloma acuminatum is significant

which can effectively promote the immunity of patients and improve the immune system.