OBJECTIVE: To probe into the efficacy of Yinzhihuang injection combined with glycyrrhizin diamine in the treatment of patients with chronic hepatitis B hepatic fibrosis and its effects on serum reactive oxygen species（ ROS）

DJ-1 and liver function. METHODS: Totally 82 patients with chronic hepatitis B hepatic fibrosis admitted into Bayannur Hospital of Inner Mongolia from Oct. 2016 to Oct. 2019 were extracted to be divided into the control group（ n = 41） and the research group（ n = 41） via the random number table. The control group was treated with glycyrrhizin diamine

while the research group received Yinzhihuang injection combined with glycyrrhizin diamine.Serum ROS

DJ-1 protein levels

serological indicators

liver fibrosis indicators [type Ⅲ procollagen（ PC-Ⅲ）

laminin（ LN）

hyaluronic acid（ HA） and type Ⅳ collagen（ Ⅳ-C） ] and the correlation between serum ROS and DJ-1 protein of two groups before and after treatment were observed. RESULTS: Serum ROS and DJ-1 protein levels in the research group were significantly lower than those in the control group after treatment

and the difference was statistically significant（ P < 0. 05）. After treatment

the levels of alanine aminotransferase

aspartate aminotransferase and total bilirubin in the research group were significantly lower than those in the control group

and the thrombin time was significantly longer than that in the control group

with statistically significant difference（ P < 0. 05）. The levels of PC-Ⅲ

LN

HA and IV-C in the research group were significantly lower than those in the control group after treatment

and the difference was statistically significant（ P < 0. 05）. The results of Pearson correlation analysis showed that serum ROS levels in patients with chronic hepatitis B hepatic fibrosis were significantly positively correlated with DJ-1 expression levels

and serum ROS levels and DJ-1 expression levels in patients with chronic hepatitis B fibrosis were positively correlated with liver fibrosis indicators（ PC-Ⅲ

LN

HA and MAR-C）.CONCLUSIONS: Yinzhihuang injection combined with glycyrrhizin diamine in the treatment of patients with chronic hepatitis B hepatic fibrosis can improve the serum ROS

DJ-1 protein and liver function levels of the patients

delay the process of liver fibrosis

and promote the more significant therapeutic effect.