OBJECTIVE: To probe into the efficacy and safety of modified Wumei pill combined with esomeprazole magnesium enteric-coated tablets in the treatment of chronic atrophic gastritis（ CAG）. METHODS: Totally 88 patients with CAG admitted into Characteristic Medical Center of PAP from Dec. 2015 to Dec. 2016 were extracted to be randomly divided into the observation group and the control group

with 44 cases in each group. The control group was treated with oral esomeprazole magnesium enteric-coated tablets

while the observation group received modified Wumei pill combined with esomeprazole magnesium enteric-coated tablets. After one course of treatment

traditional Chinese medicine（ TCM） syndrome score

clinical efficacy

endoscopic histopathological score

serological indicators[C-reactive protein（ CRP）

procalcitonin（ PCT） and gastrin-17（ G-17） ]and the incidence of adverse drug reactions of two groups were compared. RESULTS:（ 1） In terms of TCM syndrome scores

the total TCM syndrome scores in both groups after treatment were significantly lower than those before treatment

and the reduction in the observation group was more significant

the difference was statistically significant（ P < 0. 05）.（ 2） In terms of clinical efficacy

the total effective rate of the observation group and the control group was respectively 79. 5%（ 35/44） and 70. 5%（ 31/44）

the observation group was significantly higher than the control group

and the difference was statistically significant（ P < 0. 05）.（ 3） In terms of endoscopic histopathological examination

the histological scores of both groups after treatment were lower than those before treatment

but there was no statistically significant difference between two groups after treatment（ P > 0. 05）.（ 4） In terms of serological indicators

the levels of G-17

PCT and CRP in the observation group were significantly improved after treatment compared with those before treatment

and the improvement was more significant than that in the control group

with statistically significant difference（ P < 0. 05）.（ 5） In terms of adverse drug reactions

the incidence of adverse drug reactions in the observation group was 11. 4%（ 5/44）

significantly lower than 18. 2%（ 8/44） in the control group

the difference was statistically significant（ P <0. 05）. CONCLUSIONS: Modified Wumei pill combined with esomeprazole magnesium enteric-coated tablets in the treatment of CAG can effectively relieve the clinical symptoms

and significantly improve gastric mucosa atrophy with lower incidence of adverse drug reactions and higher clinical therapeutic value.