OBJECTIVE: To probe into the application rationality and drug utilization of lienal polypeptide injection in children.METHODS: Medical history of 296 children treated with lienal polypeptide injection in a certain children’s hospital from Jun.2018 to May 2019 were randomly extracted

combining with the drug instructions

the"Prescription Management Measures"

the"Expert Consensus on Clinical Use of Immunomodulators in Children"and the age and weight of children

a scoring standard for the clinical rational application of lienal polypeptide injection on children was established

including 7 indicators of indications

drug dosage

solvent type

drug concentration

administration frequency

drug combination and immune function examination

the rationality of each indicator was evaluated

and 1 point scored when rational

the rational rate and total points were calculated

so as to preliminarily discuss the evaluation method of rational application of lienal polypeptide injection in children.RESULTS: Results of medication evaluation showed that the scoring rates from high to low were respectively drug dosage（ 100%

296 cases）

solvent type（ 100%

296 cases）

administration frequency（ 100%

296 case）

drug indications（ 97.97%

290 cases）

drug combination（ 95.61%

283 cases）

drug concentration（ 79.73%

236 cases）

immune function examination（ 61.82%

183 cases）.Results of analysis on children’s weight showed that the amount of medicine used per unit body weight was negatively correlated with body weight.Results of drug utilization analysis showed that the dose of children drug utilization index（ dCDUI） decreased with the increase of weight

and the d CDUI of children with low birth weight was >1

there was excessive application; the d CDUI of children with high body weight was <1

there was insufficient application.All the concentration of children drug utilization index（ cCDUI） of children in different weight groups was >1

there was over-concentration application.CONCLUSIONS: The application of lienal polypeptide injection in children should be standardized to promote rational drug application.