OBJECTIVE: To investigate the clinical application and adverse drug reactions of Annao tablets

and to analyze its potential risk factors in the course of drug administration

so as to provide reference for further standardizing clinical medication.METHODS: Medical record and medical orders of 546 patients treated with Annao tablets in Fuxing Hospital Affiliated to Capital Medical University（ hereinafter referred to as "our hospital"） in 2019 were retrieved from hospital information system

retrospective research was adopted to analysis the basic information

disease diagnosis

clinical department

usage and dosage

drug combination and adverse drug reactions of patients

rationality analysis was conducted on the clinical application of Annao tablets in order to look for the relevant factors to adverse drug reactions.RESULTS: Among the 546 patients treated with Annao tablets

257 cases were male（ 47.07%）

289 cases were female（ 52.93%）; with the average age was（ 75.18±18.23） years old

72.34%（ 395 cases） were aged over60 years old; mainly distributed in department of traditional Chinese medicine（ 195 cases

35.71%）

department of neurology（ 170 cases

31.14%） and department of ICU（ 136 cases

24.91%）; the high frequency diagnoses were respectively cerebrovascular disease and related diagnosis（ 295 cases

54.03%）

high fever and related diagnosis（ 165 cases

30.22%）

hypertension and related diagnosis（ 56 cases

10.26%）; in terms of usage and dosage

92.31%（ 504 cases） had a single daily dose within the prescribed range of drug instruction; the course of treatment was concentrated in 7-30 days（ 442 cases

80.95%）.In the medication records

98.17% of patients（ 536 cases） were given combined medication

with an average of 8.53 drugs for combination; in terms of combined application of Annao tablets and western medicines

the high frequently used western medicines were respectively antiplatelet drugs

blood lipid regulating drugs and cerebrovascular drugs

the high frequently used antibiotics in drug combination was cephalosporins for accompanying infection; in the combined application of Annao tablets and traditional Chinese medicines

the most frequently used traditional Chinese medicines were blood-invigorating and stasis-removing

heatclearing and toxicity-removing

liver-pacifying and wind-extinguish.9 cases of adverse drug reactions/events occurred

with the incidence rate was 1.65%; unreasonable indications

unreasonable usage and dosage

and unreasonable drug combination medication were probably the potential risk factors for adverse drug reactions of Annao tablets.CONCLUSIONS: There are problems of without TCM indications

overdose and unreasonable drug combination in the use of Annao tablets in our hospital

the medication review

propaganda and education on rational medication

and effective pharmaceutical intervention should be strengthened

and the liver and kidney functions of patients need to be monitored to reduce the occurrence of adverse drug reactions and promote clinical rational application.