OBJECTIVE: To explore the antibacterial and anti-inflammatory effects of Fu’an Xiaozhen lotion in vitro

so as to provide basis for clinical rational drug use.METHODS: The antibacterial effects of original solution

50%

25% and 12.5% Fu’an Xiaozhen lotion on Staphylococcus aureus

Pseudomonas aeruginosa

Escherichia coli and Candida albicans were investigated by plate dilution method.The mouse model was established

and 60 healthy mice were divided into the blank group

the model group

the Jingui lotion group and Fu’an Xiaozhen lotion group（ including low

medium and high concentration group）

with 10 cases in each group.The anti-inflammatory effects of different concentrations of Fu’an Xiaozhan lotion on ear swelling in mice induced by dinitrochlorobenzene（ DNCB）were observed.RESULTS: The original solution

50%

25% and 12.5% of Fu’an Xiaozhen lotion had different degrees of antibacterial effects on S.aureus

P.aeruginosa

E.coli and C.albicans

with the dose-effect relationship.Compared with the model group

there was statistically significant difference in anti-inflammatory effects of mediumconcentration and high-concentration Fu ’an Xiaozhen lotion（ P < 0.05）.The anti-inflammatory effects of Fu ’an Xiaozhen lotion on DNCB increased with the increasing concentration of the lotion.CONCLUSIONS: Fu’an Xiaozhen lotion has significant antibacterial and anti-inflammatory effects

which is suitable for the treatment of diseases related to bacterial infection and inflammation in gynecology and dermatology.